Review Articles: A Focus on Gene-Related Tooth Development

Authors

  • Nuthamol Ampawa Department of Oral biology and occlusion, Faculty of Dentistry Prince of Songkla university, Hat Yai, Songkhla 90110, Thailand.
  • Ranida Ampa Department of Oral biology and occlusion, Faculty of Dentistry Prince of Songkla university, Hat Yai, Songkhla 90110, Thailand.
  • Nattapon Rotpenpian Department of Oral biology and occlusion, Faculty of Dentistry Prince of Songkla university, Hat Yai, Songkhla 90110, Thailand.

Keywords:

Tooth development, Gene, Dental mesenchyme, Morphogenesis, Teeth

Abstract

Human teeth are vertebrate-specific structures involving many genes interacting in their development, which can lead to anomalies occurring in the disturbance of these genes expression. There is little summarized knowledge of gene related tooth development, therefore, this article reviewed these genes during tooth development. Tooth development stages can be classified as initiation, proliferation and morphogenesis, cell differentiation, hard tissue genesis, and root formation. In the initiation stage of tooth development, there are LIM homobox genes such as Lhx6 and Lhx7 of activated mesenchymal cells at the oral region and Dlx1-7 develop at the inter-arch within the brachial region. Also, in this stage, Fgf8, Barx1, and Dlx2 are expressed proximally overlying the presumptive molar field. BMP4 regulates the expression of MSX1 and MSX 2 which are expressed distally overlying the presumptive incisor filed. The Lymphoid Enhancer-binding factor (Lef1) fromdental mesenchyme activates cell proliferation, morphogenesis, and cytodifferentiation until dentalpapilla and Sonic hedgehog (Shh) form. All of the proposed genes above cause tooth developmentin the oral cavity.

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Author Biography

Nattapon Rotpenpian, Department of Oral biology and occlusion, Faculty of Dentistry Prince of Songkla university, Hat Yai, Songkhla 90110, Thailand.

correspondence

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Published

2023-09-13

How to Cite

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Ampawa N, Ampa R, Rotpenpian N. Review Articles: A Focus on Gene-Related Tooth Development. SWU Dent J. [Internet]. 2023 Sep. 13 [cited 2024 Dec. 11];16(2):160-9. Available from: https://ejournals.swu.ac.th/index.php/swudentj/article/view/15455

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