Review Articles: A Focus on Gene-Related Tooth Development
Keywords:
Tooth development, Gene, Dental mesenchyme, Morphogenesis, TeethAbstract
Human teeth are vertebrate-specific structures involving many genes interacting in their development, which can lead to anomalies occurring in the disturbance of these genes expression. There is little summarized knowledge of gene related tooth development, therefore, this article reviewed these genes during tooth development. Tooth development stages can be classified as initiation, proliferation and morphogenesis, cell differentiation, hard tissue genesis, and root formation. In the initiation stage of tooth development, there are LIM homobox genes such as Lhx6 and Lhx7 of activated mesenchymal cells at the oral region and Dlx1-7 develop at the inter-arch within the brachial region. Also, in this stage, Fgf8, Barx1, and Dlx2 are expressed proximally overlying the presumptive molar field. BMP4 regulates the expression of MSX1 and MSX 2 which are expressed distally overlying the presumptive incisor filed. The Lymphoid Enhancer-binding factor (Lef1) fromdental mesenchyme activates cell proliferation, morphogenesis, and cytodifferentiation until dentalpapilla and Sonic hedgehog (Shh) form. All of the proposed genes above cause tooth developmentin the oral cavity.Downloads
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เจ้าของบทความต้องมอบลิขสิทธิ์ในการตีพิมพ์แก่วิทยาสาร โดยเขียนเป็นลายลักษณ์อักษรแนบมาพร้อมบทความที่ส่งมาตีพิมพ์ ตามแบบฟอร์ม "The cover letter format" รวมทั้งต้องมีลายมือชื่อของผู้เขียนทุกท่านรับรองว่าบทความดังกล่าวส่งมาตีพิมพ์ที่วิทยาสารนี้แห่งเดียวเท่านั้น
