HPMC Matrix Granule Formation: Selection of Suitable Granulating Fluid

Abstract

Objective: The purpose of this study was to investigate and select the suitable granulating fluid for the matrix granules consisting of hydroxypropyl methylcellulose (HPMC).Method: Viscosity of the granulating fluids containing HPMC in different solvents was determined. The matrix granules obtained from mixing the granulating fluid with propranolol HCl, HPMC and lactose were assessed for bulk density, particle size distribution, flowability and friability. SEM, DSC, powder x-ray diffraction and drug dissolution studies were conducted to characterize the physical properties of the granules.Results: Type of granulating liquid affected the granule properties. The utilization of isopropyl alcohol as a granulating liquid and subsequently adding with water was a suitable system for agglomeration of powders. Good physical properties were obtained for the granule prepared by using this granulating fluid.Conclusion: Type of solvent and amount of water played an important role for physical properties of HPMC in the formation of the matrix granule due to the hydrophilicity and gel formation of this polymer. The use of isopropyl alcohol as granulating liquid and subsequently adding with water was a suitable process in producing the matrix granules consisting of HPMC.Keywords: hydroxypropyl methylcellulose, matrix granule, granulating fluid