Antimicrobial Activity of Hexane and Dichloromethane Extracts from Momordica cochinchinensis (Lour.) Spreng Leaves

Abstract

Objective: To determine antimicrobial activity of hexane and dichloromethane extracts from Momordica cochinchinensis leaves.Method: Crude, partially purified hexane and dichloromethane extracts were determined for antimicrobial activity by using agar diffusion and agar dilution methods.Results: One chemical constituent was isolated and elucidated from partially purified hexane extract which it was momordica triterpenoid ester. Crude, partially purified hexane and dichloromethane extracts showed antimicrobial activity against ten pathogenic bacteria and three pathogenic fungi. Momordica triterpenoid ester also showed antifungal activity against T. mentagrophytes and C. albicans. Conclusion: Antimicrobial activity of crude and partially purified hexane and dichloromethane extracts was probably a result from many constituents in the extracts. These crude extract can be potentially used as antimicrobial compound as in the traditional medicine.Keywords: Momordica cochinchinensis leaves, antimicrobial activity