Goal Achievement of Low-Density Lipoprotein Cholesterol Levels in Patients with Ischemic Stroke and Hyperlipidemia at Prasat Neurological Institute

Abstract

Objective: To determine the goal achievement rate of LDL-C in patientswith ischemic stroke and hyperlipidemia at Prasat Neurological Institute(PNI) and incidence of adverse effects of statins namely myalgia andrhabdomyolysis. Method: With descriptive and retrospective design,patients with ischemic stroke and hyperlipidemia admitted in the stroke unitat PNI during March to September 2011 were studied by chart review. Lipidprofile levels at admission and within 1 year after discharge were recorded.Results: A total of 197 patients admitted stroke unit during March toNovember 2011. Four groups of patients were classified: patients with nodiabetes and no statin use (group A), no diabetes with statin use (group B),diabetes patients with no statin use (group C), and diabetes patients withstatin use (group D). LDL-goal achievement rates were 82.22%, 68.89%,21.74%, and 37.04% in groups A, B, C and D, respectively. Simvastatinwas the most prescribed lipid lowering agent (89.34%) with a dose range of10 to 40 mg per day. No myalgia or rhabdomyolysis was found.Conclusions: Low rates of LDL-goal achievement were found in diabeticpatients with ischemic stroke and hyperlipidemia. Most patients were onsimvastatin and no adverse effects of statin were found.Keywords: goal achievement, ischemic stroke , LDL–C, statins