Effects of Soy Protein Isolate Supplementation on Biomarkers of Cardiovascular Disease in Type 2 Diabetic Patients

Abstract

Objective: To evaluate the effect of soy protein isolate (SPI) supplementation on some circulating biomarkers of cardiovascular disease (CVD): totalhomocysteine (tHcy), folate and vitamin B12 in type 2 diabetic patients. Method: Thirty-six type 2 diabetic patients were recruited. They receivednutrition counseling and were randomized to SPI group (30 g/day of SPI containing 32 mg of isoflavones for 6 weeks) and control group (no SPIsupplement). Anthropometry, blood pressure and biomarkers of CVD were examined at baseline and at the end of 6th week of the study. Results:There were no significant differences in anthropometric parameters, blood pressure and biomarkers of CVD between the 2 groups. At week 6, levelsof either tHcy, folate, vitamin B12, or GFR between the two groups did not differ. However, in SPI group, tHcy levels were significantly decreased (P= 0.005) and folate levels were significantly increased from baseline (P = 0.002). Conclusion: This study indicated that supplementation of SPI withisoflavones potentially improves some biomarkers of CVD and may be beneficial on cardiovascular events in type 2 diabetic patients.Keyword: soy protein isolate, biomarkers, cardiovascular disease, type 2 diabetic mellitusThai Pharm Health Sci J 2010;5(4):296-300§