รูปแบบการสั่งใช้ยาลดไขมันกลุ่มสแตตินด้านขนาดยาในผู้ป่วยที่มีภาวะไขมันในเลือดสูงในโรงพยาบาลทั่วไปแห่งหนึ่ง Prescribing Patterns of Statins Dose in Patients with Dyslipidemia at A General Hospital

Abstract

Objective: To determine prescribing patterns emphasizing on initial dose ofstatins in treatment of dyslipidemia at a general hospital. Method: With aretrospective chart review, patients with initial treatment of dyslipidemiabetween August 13, 2012 and August 13, 2013 were included. Dose andlipid-lowering outcome of statins were based on risk of coronary heartdisease as guided by NCEP ATP III2 (very high risk, high risk, moderatelyhigh risk, moderate risk and low risk). Drug-related problems (DRP) werealso determined. Results were presented as frequency and percentage.Results: Of 116 patients included, 71 patients (61.2%) were female andthey had an average age 54 ± 1.25 years. LDL-C at initial treatment ofmore than 190 mg/dl was found in most patients (41.4%) with an averageof 178 ± 40.83 mg/dl. There were 47.4% of patients who were appropriatelygiven statins. Of those with inappropriate prescription (52.6%), 38.8% ofthem were prescribed with DRP of dosage too high, 1.17% with dosage toolow, and 12.1% with unnecessary drug therapy. After 3 month of treatment,107 patients were with complete follow-up LDL-C levels. Of these 107patients, 65 achieved LDL-C goal where 23 of them were prescribed withappropriate initial dose of statin and 42 with inappropriate one. No myalgiaor rhabdomyolysis was found. Conclusion: The majority patients withdyslipidemia were given statins with dose higher than recommended. Noadverse effects of statin were found.Keywords: statins, dyslipidemia, initial dose