Dextrocardia is an uncommon cardiac anomaly. The incidence of coronary artery disease in these individuals is not different from general population. Apart from standard percutaneous coronary intervention (PCI) procedure, some special technique should be considered, such as mirror image angiographic angulation, opposite-direction of catheters rotations. The authors describe a patient with dextrocardia who presented with ST-segment elevation myocardialinfarction and was successfully treated with fibrinolysis and PCI as an early invasive strategy.