Distribution of TGF-β1 C-509T polymorphism in Thai population

Abstract

Transforming growth factor beta 1 (TGF-β1) C-509T gene polymorphism has been found to be associated with severity and susceptibility of many diseases. To examine the distribution of TGF-β1 C-509T (rs1800469) gene polymorphism in Thai population, 56 samples from unrelated healthy Thai volunteers were analyzed by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The genotype frequencies of TGF-β1 C-509T polymorphisms were as follows: CC 12.5%, CT 39.3% and TT 48.2%, which showed no statistically  significant differences to those of Chinese (Han) (p=0.390), Italian (p=0.057), Serbian (p=0.554) and Brazilian (p=0.442) population. However, a statistically significant difference was observedbetween the genotype frequencies found in this study and those of Indian (p=0.005), Russian  (p=0.048), English (p=0.006), German (p=0.014), and Egyptian (p<0.0001) population. In addition, statistically significant differences were also observed between allele frequencies in Thai population in this study and those of other reported groups; including, Chinese (Han), Indian,Russian, Italian, English, German, Serbian, Egyptian, and Brazilian (p<0.05). The frequency of Tallele in Thai was significantly higher than that of C allele, whereas in other reported groups, the Callele frequencies were significantly higher than T allele frequencies (p<0.05). From the above data, it is likely that the distribution of TGF-β1 C-509T gene polymorphisms in Thai population is different from those of Asian, Caucasian, Egyptian, and Brazilian population. This observation may be useful and could be applied for treatment and prognostic of disease in the future. However, further studies in larger numbers of Thai subjects are required for confirmation.