The efficacy of low protein acne patch containing with the extracts of Garcinia mangostana Linn and dry root of Albizia saman

Abstract

Acne is a common skin disease. The alternative treatment for acne such as hydrocolloid acne patch is used for decreasing the inflammatory process. This is experimental, randomized, assessorblinded, controlled, intra-individual split face comparative study. Thirty-six volunteers with mild to moderate acne vulgaris were enrolled. The clinical outcomes were evaluated as the followings: mediantime to recovery of acne analyzed by survival analysis, lesional diameters measurement of acne, clinical erythema score, erythema index by Mexameter Mx16® (Cologne, Germany) and the patients’ s satisfaction. All the volunteers were assessed at baseline 3, 7 and 14 days. It was showed that the median time to recovery of the acne on the side that was treated with GA is 7 days, while the side that was treated with His 14 days with statistically significant difference (p=0.001). The results showed that on day 3, 7 and 14 of our visits, the group treated with GA had acne which were statistically significantly smaller in diameter size, lower clinical erythema score and lower erythema index reduction than the H group (p=1x10-6). In terms of the satisfaction, the patients were found to be more satisfied, based on satisfaction score, with thetreatment using GA than H group. This result was statistically significant difference (p=1x10-6). No adverse effects were reported from either type of patches. In conclusion, the low protein acne patch containingwith mixed extracts of Garcinia mangostana Linn and dry root of Albizia saman was effective and safe for treating acne, which was demonstrated by the more improvement than that of the hydrocolloid acne patch. As such, this can be used as an alternative inflammatory acne treatment