BNP and NT-proBNP: biomarkers for heart failure (BNP และ NT-proBNP: ตัวชี้วัดสำหรับภาวะหัวใจล้มเหลว)

Abstract

Heart failure is a condition in which a structural or functional defect of the heart impairs its ability to deliver oxygen-rich blood to meet the body's requirements. In this condition, the pressure and volume overload results in stretching of cardiac myocytes, leading to increasing brain natriuretic peptide (BNP) and amino terminal proBNP (NT-proBNP) synthesis and release. These peptides increase glomerular filtration rate and natriuresis, leading to decreasing congestion of body fluid. Therefore, the levels of BNP and NT-proBNP are related to the severity of heart failure and to clinical conditions. Clinically, these peptides have been approved as diagnostic and prognostic markers for heart failure. Moreover, nesiritide, a recombinant BNP is used to treat heart failure.