Antimicrobial activity of nisin on common dermatological pathogens

Abstract

Environmental changes and lack of proper medical treatments can induce drug resistant microbes including those from dermatological infections. Therefore, alternative and effective treatments against dermatological pathogens from natural resources and herbs become essential. This study aimed to determine a promising nisin treatment as an alternative way for preventing dermatological infections. Nisin from Lactococcus lactis was used for in vitro treating common dermatological pathogens usually found in tropical regions including Trichophyton rubrum, Candida albicans, and Staphylococcus aureus. The results showed that nisin reduced the growth of S. aureus as indicated by ที่ Minimal Inhibitory Concentration and Minimal Bactericidal Concentration (120 and 1,920 μg/ml, respectively). Moreover, 960 μg/ml of nisin was found to reduce the growth of T. rubrum and C. albicans as indicated by MIC. In addition, this concentration of nisin 120 μg/ml did not exhibit any effect on fibroblast cells in vitro. Therefore, this study demonstrated that nisin can be probably used as an alternative therapeutic agent for treating dermal infection caused by common dermatological pathogens.